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The author decided to write Middlesex after he read the 1980 memoir Herculine Barbin and was dissatisfied with its discussion of intersex anatomy and emotions.Primarily a coming-of-age story (Bildungsroman) and family saga, the novel chronicles the effect of a mutated gene on three generations of a Greek family, causing momentous changes in the protagonist's life.

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Middlesex is a Pulitzer Prize-winning novel by Jeffrey Eugenides published in 2002.

The book is a bestseller, with more than four million copies sold since its publication.

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