Occupying former theatres, railway arches, factories, warehouses and newspaper printing presses, many of London's major clubs started out as illegal party venues, and Londoners are used to descending into the ancient heart of their city for a big night out.
There's indie, rock, pop and world music in the mix, but it's all-night dance raves on the weekend that are the lifeblood of these huge spaces.
And Chris Evans put on a particularly excited display, pouring a bottle of water over his head after celebrating the end of his exhausting run.
Newsreader Sophie Raworth was also seen beaming after the run, her flawlessness seemingly unaffected by the exertion.
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The huge stage, broad balconies and plush upstairs bars are a reminder of its former role as the Camden Theatre (which originally opened its doors in 1900), and the deep red colour scheme, chandeliers and gilt molding give it a decadent air that matches the rock stars who grace the stage.
It has an illustrious rock 'n' roll history, having hosted The Clash and the Sex Pistols in the 1970s, and The Eurythmics, Madness and Madonna in the 1980s.
After agreeing a strict licensing deal with Islington Council in 2016, the club no longer admits under 19s and anyone found with drugs or dealing drugs will be banned for life.
Ko Ko offers a great mixture of live bands and club nights that have put it at the heart of the Camden nightlife.
Feel the bass bleed through the speakers buried in the floor and recline in style on the famous bed seats at one of their top regular nights.
Because it's such a famous brand, Fabric gets horribly crowded sometimes, but the best acts usually don't come on until 3am, when the tourists have gone and the hardcore clubbers have space to party.
And MP Jon Ashworth looked in equally high spirits following the charity run.